Citation

More SS, Kiran KM, Gadag JR. J. Basic Clin. Physiol. Pharmacol. 2004; 15(3-4): 263-275.

Affiliation

Karnatak University Research Laboratory, Department of Biochemistry, Toxinology Division, Karnatak University Dharwad, Dharwad-580001, Karnataka, India. sunilarc@yahoo.co.in

Copyright

(Copyright © 2004, Israel Physiological and Pharmacological Society, Publisher Freund Publishing)

DOI

unavailable

PMID

15803962

Abstract

Palamneus gravimanus envenomated rats showed dose-dependent alterations in serum biochemical parameters. Sub lethal doses of 100, 200, and 400 microg/kg of P. gravimanus venom were injected intramuscularly into rats. Blood samples were collected by heart puncture before and 4 h after crude venom administration. Serum was analyzed for glucose, blood urea nitrogen (BUN), uric acid, total protein, cholesterol, sodium, potassium, inorganic phosphorus, alkaline phosphatase, aspartate aminotransferase (AST-SGOT), alanine amino-transferase (ALT-SGPT), lactate dehydrogenase (LDH), and creatinine phosphokinase (CPK). Statistically significant increases in serum levels of glucose, creatinine, AST, ALT, BUN, CPK, and LDH and significant decreases in serum levels of total protein, uric acid, cholesterol, calcium, and potassium 4 h after venom administration could be due to the toxic action of P. gravimanus venom on certain organs in rats.

Language: en