Citation

de Leon AR, Wu B. Stat. Med. 2011; 30(2): 175-185.

Affiliation

Department of Mathematics and Statistics, University of Calgary, Calgary, Alberta, Canada T2N 1N4.

Copyright

(Copyright © 2011, John Wiley and Sons)

DOI

10.1002/sim.4087

PMID

20963753

Abstract

This paper is concerned with regression models for correlated mixed discrete and continuous outcomes constructed using copulas. Our approach entails specifying marginal regression models for the outcomes, and combining them via a copula to form a joint model. Specifically, we propose marginal regression models (e.g. generalized linear models) to link the outcomes' marginal means to covariates. To account for associations between outcomes, we adopt the Gaussian copula to indirectly specify their joint distributions. Our approach has two advantages over current methods: one, regression parameters in models for both outcomes are marginally meaningful, and two, the association is 'margin-free', in the sense that it is characterized by the copula alone. By assuming a latent variable framework to describe discrete outcomes, the copula used still uniquely determines the joint distribution. In addition, association measures between outcomes can be interpreted in the usual way. We report results of simulations concerning the bias and efficiency of two likelihood-based estimation methods for the model. Finally, we illustrate the model using data on burn injuries. Copyright © 2010 John Wiley & Sons, Ltd.

Language: en