Citation

Chen JM, Wang LX, Xia WT. Fa Yi Xue Za Zhi 2010; 26(4): 294-296.

Affiliation

Department of Forensic Medicine, Shanghai Medical College of Fudan University, Shanghai 200032, China.

Copyright

(Copyright © 2010, Si fa bu Si fa jian ding ke xue ji shu yan jiu suo)

DOI

unavailable

PMID

20967961

Abstract

The methanol poisoning by oral intake or skin contact occurs occasionally, which may have serious consequences including blindness and/or death. Methanol and its metabolites, formaldehyde and formic acid, are associated with metabolic acidosis, visual dysfunction and neurological symptoms. At present, the mechanism of methanol poisoning primarily focuses on the cell hypoxia, the alteration of structure and biological activity induced by free radical and lactic acid. Meanwhile, methanol poisoning causes changes in the balance between the production of free radicals and antioxidant capacity and in the proteases-protease inhibitors system, which lead to a series of disturbances.

Language: zh