Citation

Fendt M, Buchi M, Bürki H, Imobersteg S, Ricoux B, Suply T, Sailer AW. Behav. Brain Res. 2011; 217(1): 1-9.

Affiliation

Novartis Institutes of BioMedical Research Neuropsychiatry.

Copyright

(Copyright © 2011, Elsevier Publishing)

DOI

10.1016/j.bbr.2010.09.022

PMID

20888368

Abstract

The present study investigated the phenotype of heterozygous and homozygous neuropeptide S receptor (Npsr) deficient C57BL/6 mice in NPS- and cocaine induced hyperactivity, spontaneous and reactive locomotor activity, elevated plus maze, conditioned fear, and prepulse inhibition of the acoustic startle response. In Npsr-deficient mice, a strong reduction of spontaneous locomotor activity and of the startle magnitude was observed; heterozygous mice had an intermediate phenotype. In the other experiments, Npsr deficiency leads to no or only a very modest phenotype. These results support an important role of neuropeptide S in regulating locomotor activity.

Language: en