Citation

Lallement G. Ann. Pharm. Fr. 2007; 65(6): 415-421.

Vernacular Title

Neurogenese reparatrice apres intoxication par un neurotoxique organophosphore.

Affiliation

Département de Toxicologie, Centre de Recherches du Service de Santé des Armées (CRSSA), 24, avenue des Maquis du Grésivaudan, BP 87, F 38702, La Tronche Cedex, France. guylallement@crssa.net

Copyright

(Copyright © 2007, Elsevier Publishing)

DOI

unavailable

PMID

18079674

Abstract

Nerve agents could be potentially used as during a conflict or a terrorist attack. If an emergency treatment is not provided after poisoning, irreversible brain damages and behavioural sequels are expected to appear. In vivo cell therapy seems to be a promising approach for delayed treatment to contribute to brain repair. A mobilization of endogenous neural progenitors would be the basis of such an approach. After migrating, these progenitors would engraft in damaged brain regions and subsequently differentiate into functional neurons. In this review, after a few reminders regarding nerve agent poisoning and the emergency treatment of such an intoxication, progresses in terms of cell therapy and its potential application to nerve agent-induced brain lesions are summarized.

Language: fr