Citation

Sledkov AI. Aviakosm. Ekolog. Med. 1996; 30(6): 24-26.

Vernacular Title

Prognozirovanie tsentral'nogo deistviia farmokologicheskikh preparatov v

Affiliation

Institute of Evolutional Physiology and Biochemistry of IM Sechenov.

Copyright

(Copyright © 1996, Institute of Biomedical Problems)

DOI

unavailable

PMID

9035793

Abstract

A new method for predicting the central effects of pharmacological preparations in hyperbaric helio- and nitrogen-oxygen environments takes into consideration the dynamics of changes in excitability of different structures of the brain in animals compared with EEG and behavioural symptoms of the high pressure nervous syndrome (HPNS), and levels of the barometric pressure. The concept of the central effect of preparations under hyperbaric conditions should be taken into account while rendering the medicamentous assistance to aquanauts directly exposed to elevated pressure. Besides, it was shown that the strategy of searching protectors against NSHP and nitrogen narcosis may consist of selecting substances which will adequately recuperate shifts in the brain excitability due to these hyperbaric pathologies.

Language: ru