Citation

Laumon B, Gadegbeku B, Martin JL, Biecheler MB. Br. Med. J. BMJ 2005; 331(7529): 1371.

Affiliation

French National Institute for Transport and Safety Research (INRETS), Epidemiological Research and Surveillance Unit in Transport, Occupation and Environment (UMRESTTE), 25 avenue Francois Mitterrand, F-69675 Bron Cedex.

Copyright

(Copyright © 2005, BMJ Publishing Group)

DOI

10.1136/bmj.38648.617986.1F

PMID

16321993

PMCID

PMC1309644

Abstract

OBJECTIVES: To evaluate the relative risk of being responsible for a fatal crash while driving under the influence of cannabis, the prevalence of such drivers within the driving population, and the corresponding share of fatal crashes. DESIGN: Population based case-control study. PARTICIPANTS: 10 748 drivers, with known drug and alcohol concentrations, who were involved in fatal crashes in France from October 2001 to September 2003. MAIN OUTCOME MEASURES: The cases were the 6766 drivers considered at fault in their crash; the controls were 3006 drivers selected from the 3982 other drivers. Positive detection of cannabis was defined as a blood concentration of Delta(9)tetrahydrocannabinol of over 1 ng/ml. The prevalence of positive drivers in the driving population was estimated by standardising controls on drivers not at fault who were involved in crashes resulting in slight injuries. RESULTS: 681 drivers were positive for cannabis (cases 8.8%, controls 2.8%), including 285 with an illegal blood alcohol concentration (>/=0.5 g/l). Positive cannabis detection was associated with increased risk of responsibility (odds ratio 3.32, 95% confidence interval 2.63 to 4.18). A significant dose effect was identified; the odds ratio increased from 2.18 (1.22 to 3.89) if 0 /=5 ng/ml. The effect of cannabis remains significant after adjustment for different cofactors, including alcohol, with which no statistical interaction was observed. The prevalence of cannabis (2.9%) estimated for the driving population is similar to that for alcohol (2.7%). At least 2.5% (1.5% to 3.5%) of fatal crashes were estimated as being attributable to cannabis, compared with 28.6% for alcohol (26.8% to 30.5%). CONCLUSIONS: Driving under the influence of cannabis increases the risk of involvement in a crash. However, in France its share in fatal crashes is significantly lower than that associated with positive blood alcohol concentration.

Keywords: Cannabis impaired driving