Citation

Geeraerts T, Haïk W, Tremey B, Duranteau J, Vigue B. Ann. Fr. Anesth. Reanim. 2010; 29(9): e177-81.

Vernacular Title

Troubles de la coagulation lors du traumatisme cranio-encephalique:

Affiliation

Département d'anesthésie-réanimation chirurgicale, hôpital de Bicêtre, AP-HP, faculté de médecine, université Paris Sud, 78, rue du Général-Leclerc, 94275 Le-Kremlin-Bicêtre, France.

Copyright

(Copyright © 2010, Elsevier Publishing)

DOI

10.1016/j.annfar.2010.06.007

PMID

20655167

Abstract

Early activation of coagulation is common after traumatic brain injury. Its origin is probably mainly intracerebral, due to tissue factor release from the injured brain. Abnormalities in blood coagulation tests are associated with poor neurological prognosis. Coagulation activation may induce disseminated intravascular coagulation and fibrinolysis. Disseminated intravascular coagulation is linked to brain ischemia caused by intravascular microthrombosis. This review will focus on pathophysiology of coagulation disorders after traumatic brain injury, and on their implications for therapeutic approaches.

Language: fr