Citation

Lee YC, Lin JL, Lee SY, Hsu CW, Weng CH, Chen YH, Yang CW, Yen TH. Hum. Exp. Toxicol. 2011; 30(7): 528-534.

Affiliation

Department of Nephrology and Division of Clinical Toxicology, Chang Gung Memorial Hospital, Taipei, Taiwan.

Copyright

(Copyright © 2011, SAGE Publishing)

DOI

10.1177/0960327110377524

PMID

20630915

Abstract

Introduction: Lithium is a popular medication for bipolar disorder, but very little work has been done to study Asian patients with lithium poisoning. Methods: A total of 21 out of 7140 poisoned patients were referred for management of lithium poisoning between 2000 and 2009. Patients were stratified according to blood lithium level, that is mild-to-moderate (<2.5 mEq/L) or severe (>/=2.5 mEq/L) poisoning. Demographic, clinical, and laboratory data were obtained for analysis. Mortality rates were also analyzed. Results: There were no significant differences between both groups for the baseline variables such as poisoning patterns, age, sex, smoking habit, alcohol consumption, or medical history of diabetes mellitus or hypertension (p > 0.05). Patients with severe poisoning had a greater distribution of severe neurological symptoms (mild/moderate/severe: 11.1%/44.4%/44.4% versus 58.35%/16.65%/8.3%, p < 0.05), cardiovascular symptoms (66.6% versus 16.6%, p < 0.05), and renal impairment (urea nitrogen/creatinine: 27.1 +/- 17.8/ 1.9 +/- 1.3 mg/dL versus 14.1 +/- 7.1/ 1.3 +/- 0.6 mg/dL, p < 0.05) than patients with mild-to-moderate poisoning. Most patients were treated with saline diuresis (9 patients 100% with severe poisoning versus 9 patients 75.0% with mild-to-moderate poisoning, p > 0.05). Hemodialysis was initiated in 2 (22.2%) of 9 and 1 (8.3%) of 12 patients with severe and mild-to-moderate poisoning, respectively (p > 0.05). The treatment was successful and all patients recovered without chronic sequelae. Thus, these favorable outcomes were comparable to the data from other international Poison Centers. Conclusions: Given the excellent outcomes of detoxification protocols, patients undergoing lithium therapy must be closely monitored for its toxicity and treated immediately in case of poisoning.

Language: en