Citation

Finkelstein Y, Milatovic D, Lazarovici P, Ophir A, Richter ED, Aschner M, Lecht S, Marcinkiewicz C, Lelkes PI, Zaja-Milatovic S, Gupta RC, Brodsky B, Rosengarten A, Proscura E, Shapira E, Wormser U. Neurotoxicology 2010; 31(5): 608-620.

Affiliation

Service and Unit of Neurology and Toxicology, Shaare Zedek Medical Center, Jerusalem, Israel.

Copyright

(Copyright © 2010, Elsevier Publishing)

DOI

10.1016/j.neuro.2010.06.009

PMID

20620165

Abstract

The increasing exposure to environmental neurotoxicants in the last decades caused serious health problems in the world population. Some of the neurotoxic agents are being used in agriculture and household such as insecticides and rodenticides and others are of natural origin like snake and scorpion venoms. Additional group of harmful substances is the chemical warfare agents including nerve and blistering agents that are known for their disastrous effects on neuronal tissues. The present paper presents a combination of epidemiological/clinical and molecular approaches for investigating the effect of certain groups of neurotoxicants on a variety of pathologies. The work of Finkelstein and coworkers describes epidemiological and clinical studies on acute and chronic organophosphate (OP)-induced neurotoxicity in certain populations in Israel. They mainly investigated the neurotoxic effects of low-level long-term exposure to OP in agricultural areas but also dealt with acute exposures as well. A molecular approach to OP mechanism of neuronal injury was described by Milatovic and coworkers. They demonstrated OP-induced oxidative injury in pyramidal neurons in the CA1 hippocampal area and its suppression by antioxidants. Lecht and coworkers described the novel snake venom angioneurins as important mediators of the physiological cross-talk between the cardiovascular and nervous systems. They also showed that under certain conditions these angioneurins may induce pathologies such as tumor development or disruption of the vascular barrier function during envenomation. Additional mechanistic/therapeutic approach was presented Brodsky, Rosengarten, Proscura, Shapira and Wormser. They developed a novel antiinflammatory peptide that reduced skin irritation induced by heat and sulfur mustard (SM) stimuli. Since SM causes neuropsychiatric symptoms and alterations in neurological functions this peptide may serve as a potential treatment of neuronal injuries caused by environmental neurotoxicants. These reviews highlight different aspects of neurotoxicity, addressing epidemiology and mechanisms of toxicity; and identifying novel potential therapies.

Language: en