Citation

Fidecka S, Langwínski R. J. Physiol. Pharmacol. 1995; 46(4): 429-437.

Affiliation

Department of Pharmacodynamics, Medical Academy, Lublin, Poland.

Copyright

(Copyright © 1995, Polish Physiological Society)

DOI

unavailable

PMID

8770787

Abstract

Ethanol has pharmacological profile very similar to benzodiazepines which facilitate GABA-ergic neurotransmission. In addition, a lot of ethanol-induced effects are partially antagonized by Ro 15-4513, a benzodiazepine inverse agonist. In our study, the influence of CGS 8216, another benzodiazepine inverse agonist, on the hypothermic (3.5 g/kg in mice, 3.0 g/kg in rats) and disturbing the motor coordination (3.2 g/kg in mice, 2.5 g/kg in rats, aerial righting reflex) effects of ethanol was investigated. The hypothermic effects of ethanol were antagonized in mice, and significantly attenuated in rats by CGS 8216 (10 and 20 mg/kg). Ethanol-induced motor incoordination was significantly diminished by 10 and 20 mg/kg of CGS 8216 in mice but not in rats. These data suggest that some effects of ethanol may result from the intensification of benzodiazepine/GABA-ergic activity. In addition, they let us presume that the activity of CGS 8216 is connected with a benzodiazepine receptor named BZ-1 or omega 1. The results indicate the need of further work on the benzodiazepine inverse agonists for use in treatment of ethanol poisoning.

Language: en