Citation

Alam MI, Auddy B, Gomes A. Toxicon 1994; 32(12): 1551-1557.

Affiliation

Department of Physiology, University of Calcutta, India.

Copyright

(Copyright © 1994, Elsevier Publishing)

DOI

unavailable

PMID

7725324

Abstract

An organic acid, isolated and purified from the root extract of an Indian medicinal plant sarsaparilla Hemidesmus indicus R. Br, possessed viper venom inhibitory activity. The compound (designated HI-RVIF) was isolated by solvent extraction, silica gel column chromatography and thin layer chromatography, and was homogeneous in nature. The white needle-shaped crystals were soluble in water, methanol and chloroform and had a melting point of 155-158 degrees C and lambda max 260 nm. Spectral analysis confirmed the presence of a benzene ring, methoxy group, and hydroxyl group; the mol. wt of the compound was 168. HI-RVIF significantly antagonized viper venom-induced lethal, haemorrhagic, coagulant and anticoagulant activity in experimental rodents.

Language: en