Citation

Dulícek P, Chrobák L, Podzimek K, Voglová J. Vnitr. Lek. 1994; 40(1): 32-35.

Vernacular Title

Smrtelny krvacivy stav po poziti rodenticid.

Affiliation

Oddĕlení klinické hematologie FN Hradec Králové.

Copyright

(Copyright © 1994, Avicenum)

DOI

unavailable

PMID

8140748

Abstract

The authors describe a fatal haemorrhagic condition in a 53-year-old man which developed after assumed ingestion of so-called "superwarfarins". Symptoms of intoxication with substances of the warfarin type include the sudden development of haemorrhagic diathesis, marked prolongation of INR and APTT with persisting pathological values of these tests after the usual substitution doses of vitamin K1. The fluctuation of INR and APTT values during repeated examinations is also striking. In the event of such a coagulation finding it is important to consider possible superwarfarin intoxication, even if it is difficult to provide direct evidence, as it is not possible to assess the ratio of vitamin K1 and K 1, 2, 3 epoxide.

Language: cs