Citation

Nantwi KD, Schoener EP. Life Sci. 1993; 53(19): PL327-30.

Affiliation

Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201.

Copyright

(Copyright © 1993, Elsevier Publishing)

DOI

unavailable

PMID

8412507

Abstract

In vivo electrophysiological experiments were conducted to examine the responses of single, spontaneously-active neostriatal neurons to repeated cocaine exposure. The second of two administrations in a 30 min interval, attenuated the magnitude and duration of cocaine-induced depression in discharge rate, and enhanced the same variables for cocaine-evoked excitation. These findings indicate that the responsiveness of striatal neurons to cocaine may vary predictably as a function of previous exposure.

Language: en