Citation

Kumar P. Ann. Plast. Surg. 2010; 65(1): 74-79.

Affiliation

From the Department of Plastic Surgery and Burns, Kasturba Medical College, Manipal, Karnataka, India.

Copyright

(Copyright © 2010, Lippincott Williams and Wilkins)

DOI

10.1097/SAP.0b013e3181c47d71

PMID

20548219

Abstract

Capillary permeability increases after inflammation with consequent leak of fluid, electrolytes, and proteins. The albumin molecule size being smaller (69 kDa) than the globulin molecule (90-156 kDa) will leak relatively at an early stage of the disease (with moderate increase in capillary pore size) than globulin leading to albumin/globulin reversal. In cases with severe permeability changes with rapid progression to larger pore size with simultaneous leak of both albumin and globulin, albumin/globulin reversal will not occur. In this study estimation the serum protein and albumin/globulin (A/G) ratio at frequent intervals was done to grade the severity of the condition of burn patients by assessing the severity of capillary leak.A total of 61 admitted patients (from March 2002 to December 2004) based on the protein values were divided into 3 groups (group 1: 6-8 g/dL, group 2: 5.1-5.9 g/dL, group 3:

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