Citation

Miller B, Alaräisänen A, Miettunen J, Järvelin MR, Koponen H, Rasanen P, Isohanni M, Kirkpatrick B. J. Nerv. Ment. Dis. 2010; 198(6): 404-411.

Affiliation

Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, Georgia; Department of Psychiatry, University of Oulu, Oulu, Finland; Division of Epidemiology, Public Health, and Primary Care, Imperial College, London, United Kingdom; Department of Public Health and General Practice, University of Oulu, Oulu, Finland; and Department of Psychiatry, University of Kuopio, Kuopio, Finland.

Copyright

(Copyright © 2010, Lippincott Williams and Wilkins)

DOI

10.1097/NMD.0b013e3181e07d79

PMID

20531118

Abstract

Advanced paternal age is a risk factor for adverse health outcomes in the offspring. In a population-based birth cohort from Finland, 10,965 singleton offspring born in 1966 and alive at age 1 were followed to age 39. Hazard ratios were calculated, adjusting for maternal age, gender, paternal social class, and maternal parity. In females but not in males, increasing paternal age was associated with a linear increased risk of suicide (hazard ratio [HR] = 1.13, 95% confidence interval [CI] = 1.04-1.24, p < 0.01) and all-causes mortality (HR = 1.06, 95% CI = 1.01-1.10, p = 0.02). Increasing maternal age was associated with a significantly decreased risk of suicide (HR = 0.93, 95% CI = 0.86-1.00, p = 0.04) and all-causes mortality (HR = 0.96, 95% CI = 0.93-1, p = 0.02) in the entire cohort. For paternal age >/=30, the population attributable risk percentage was 13.7% for all deaths and 7.5% for suicides. Parental age at birth may affect suicide and all-causes mortality risk in the offspring in the general population. The causal pathways and specific disorders associated with this increased mortality are largely unknown.

Language: en