Citation

Commandeur D, Danguy Des Deserts M, Giacardi C, Eyrieux S, Ould-Ahmed M, Drouillard I. Ann. Biol. Clin. (JLE) 2010; 68(2): 234-238.

Vernacular Title

Pharmacocinetique des marqueurs biologiques d'une intoxication medicamenteuse

Affiliation

Département d'anesthesie-reanimation,, Federation des laboratoires, Hopital d'instruction des armees Clermont-Tonnerre, Brest.

Copyright

(Copyright © 2010, John Libbey Eurotext)

DOI

10.1684/abc.2010.0421

PMID

20348051

Abstract

We report the case of a 35-year-old woman hospitalized in intensive care unit after valpromide self-poisoning (Dépamide(R)). The dose supposed to be taken was 15 g. The patient eleven hours after ingestion, presented, a coma with bilateral non-reactive mydriasis, justifying intubation and mechanical ventilation. An acidosis (pH = 7.24), a hyperlactatemia (2.72 mmol/L), a hyperammonemia (328.9 mumol/L), and were diagnosed valproic acid plasmatic concentration was 1190 mug/mL at 22 hours. Symptomatic treatment and L-carnitine therapy (50 mg/kg/12h) normalized the action of biological abnormalities and allowed disappearance of symptoms; the patient was extubated after 46 hours, and outcome from intensive care unit at 65 hours.

Language: fr