Citation

Bianchetti MG, Beutler A, Ferrier PE. Helv. Paediatr. Acta 1988; 43(3): 241-244.

Vernacular Title

Intoxication severe avec un opiace (Tramadol) chez un nourrisson de cinq

Affiliation

Clinique de Pédiatrie, Hôpital cantonal universitaire, Genève, Suisse.

Copyright

(Copyright © 1988, Schwabe)

DOI

unavailable

PMID

3220791

Abstract

Accidental rectal administration of 27 mg/kg of the narcotic analgesic Tramadol to a five-week-old infant resulted in severe cerebral depression, which had to be treated with Naloxone during 48 hours. The severity and the duration of this intoxication are not explained solely by the high dosage of Tramadol. A decreased elimination kinetics and an increased permeability of the blood-cerebrospinal fluid barrier probably also account for the pattern of the present intoxication.

Language: fr