Citation

Sugama S, Kusano K, Okazaki M, Eto Y. Rinsho Shinkeigaku 1992; 32(8): 890-892.

Affiliation

Department of Pediatrics Tokyo Jikei University School of Medicine, Aoto Hospital.

Copyright

(Copyright © 1992, Societas Neurologica Japonica)

DOI

unavailable

PMID

1490319

Abstract

The neuroendocrinological examinations were performed in mentally retarded 7-year-old boy with severe self-injurious behavior (SIB). The thyroid-stimulating hormone (TSH) and prolactine responses to TRH showed lower in the basal and peak levels compared with those in the age matched control group. It is suggested that there may be an enhanced dopaminergic activity. The effects of naloxone, clomipramine and sulpiride on the frequency of SIB were investigated in this case. The frequency of SIB was reduced by sulpiride; a dopamine antagonist. These data suggest dopaminergic supersensitivity and hypothalamic dysregulation as a mechanism underlying SIB.

Language: ja