Citation

Corrigan MH, Gillette GM, Quade D, Garbutt JC. Biol. Psychiatry 1992; 31(10): 984-992.

Affiliation

Dorothea Dix Hospital Clinical Research Unit, Raleigh, NC 27611.

Comment In:

Biol Psychiatry 1993;34(7):503-4

Copyright

(Copyright © 1992, Elsevier Publishing)

DOI

unavailable

PMID

1511081

Abstract

We investigated the relationship between suicidality, agitation, panic attacks, and the thyrotropin-stimulating hormone (TSH) response to thyrotropin-releasing hormone (TRH), and tested the hypothesis that panic would account for the association between a reduced TSH response and the other conditions. Twenty-seven euthyroid primary unipolar depressed inpatient women received a TRH test and systematic psychiatric assessment. Panic attacks were insufficient to explain the link between the TSH response and suicidal intent, lethality, and agitation; each condition was independently associated with a lower TSH response. In an additive fashion, copresence of conditions further reduced TSH response. The symptom constellation of panic, agitation, and suicidality in depression may correlate with the greatest reduction in TSH response.

Language: en