Citation

De Paermentier F, Cheetham SC, Crompton MR, Katona CL, Horton RW. Psychopharmacology 1991; 105(2): 283-288.

Affiliation

Department of Pharmacology and Clinical Pharmacology, St. George's Hospital Medical School, London, UK.

Copyright

(Copyright © 1991, Holtzbrinck Springer Nature Publishing Group)

DOI

unavailable

PMID

1686657

Abstract

beta-Adrenoceptor binding sites were measured by saturation binding of 3H.CGP 12177 in nine brain regions from 13 suicides, with a firm retrospective diagnosis of depression, who had been receiving antidepressant drugs, and 11 matched controls. Significantly lower numbers of beta-adrenoceptor binding sites were found in thalamus and temporal cortex (Brodmann area 38), but not in other brain regions, of antidepressant-treated suicides compared to controls. The lower number of beta-adrenoceptor binding sites in thalamus appeared to be related to drug treatment, whereas lower numbers of beta-adrenoceptors in temporal cortex were also found in antidepressant-free suicides.

Language: en