Citation

Matsubara S, Arora RC, Meltzer HY. J. Neural. Transm. 1991; 85(3): 181-194.

Affiliation

Department of Psychiatry, Hokkaido University School of Medicine, Japan.

Copyright

(Copyright © 1991, Holtzbrinck Springer Nature Publishing Group)

DOI

unavailable

PMID

1834090

Abstract

The density of 5-HT1A binding using 3H-8-hydroxy-2-(di-n-propyl-amino) tetralin (8-OH-DPAT) as binding ligand, was studied in human frontal cortex of suicide victims and normal controls who died due to medical disease or accidentally. There was no difference in the maximum number of binding site (Bmax) or Kd (an inverse measure of affinity) of 5-HT1A receptor binding sites between normal controls and the entire group of suicide victims. However, nonviolent suicides had significantly higher Bmax (22-25%) compared to both controls and violent suicides. A negative correlation between age and Bmax of 5-HT1A binding sites was found in male controls but not in female controls or suicide victims. This relationship was less apparent among the male controls over age 60.

Language: en