Citation

Marazziti D, Conti L. Acta Psychiatr. Scand. 1991; 84(3): 209-211.

Affiliation

Institute of Psychiatry Clinic, University of Pisa, Italy.

Copyright

(Copyright © 1991, John Wiley and Sons)

DOI

unavailable

PMID

1659117

Abstract

We measured platelet 3H-imipramine binding parameters in 16 subjects affected by different types of mental deficiency, all characterized by hyperactive and/or aggressive behaviour, and in 16 healthy controls. The patients had a lower maximum binding capacity than the controls, with no difference in Kd, irrespectively of the type of mental disorder. These findings suggest a link between 5-HT disturbances, reflected by reduced imipramine binding sites, and behavioural dyscontrol, expressed as hyperactivity and aggression.

Language: en