Citation

Träskman-Bendz L, Åsberg M, Nordström P, Stanley M. Prog. Neuropsychopharmacol. Biol. Psychiatry 1989; 13(Suppl): S35-44.

Affiliation

Dept. Psychiatry, Lund University Hospital, Sweden.

Copyright

(Copyright © 1989, Elsevier Publishing)

DOI

unavailable

PMID

2616793

Abstract

1. In completed suicides, studies of brain regions and CSF indicate a dysfunction of the serotonergic system. 2. In suicidal patients, regardless of diagnoses, analyses of monoamine metabolites in lumbar CSF reveal decreased concentrations of the serotonin metabolite 5-HIAA. 3. In depressed suicidal patients, both low CSF 5-HIAA and low concentrations of the dopamine metabolite HVA are associated with suicidality. In addition, pathological dexamethasone-tests may indicate an increased suicide-risk in these patients. 4. In depressed patients, there is evidence that the association between CSF 5-HIAA and corticosteroids is in contrast to findings in depressed suicidal patients.

Language: en