Citation

Grande LJ, Crosson B, Heilman KM, Bauer RM, Kilduff P, McGlinchey RE. Neuropsychology 2006; 20(3): 370-382.

Affiliation

Geriatric Research Education and Clinical Center, Boston VA Healthcare System, and Department of Psychiatry, Harvard Medical School, Boston, MA 02130, USA. lgrande@heartbrain.com

Copyright

(Copyright © 2006, American Psychological Association)

DOI

10.1037/0894-4105.20.3.370

PMID

16719630

Abstract

Impairment in the inhibitory mechanism of visual selective attention in patients with Parkinson's disease (PD) is controversial. The present study sought to understand disparate findings in a manner analogous to the relative preservation of exogenously evoked movement and impairment of endogenously evoked movement. The authors examined inhibition of return (i.e., exogenously evoked inhibition; IOR) and negative priming (i.e., endogenously evoked inhibition; NP) in a group of 14 patients with PD and 14 healthy controls (HC). Unlike the HC, who demonstrated significant inhibition in both tasks, the group with PD demonstrated intact inhibition only in the IOR task. Dopamine replacement therapy did not affect performance. The findings are discussed within the context of a model that differentiates the essential involvement of the basal ganglia for endogenously evoked spatial inhibition.

Language: en