Citation

Isbister GK, Murray L, John S, Hackett LP, Haider T, O'Mullane P, Gosselin S, Daly FF. Med. J. Aust. 2006; 184(7): 354-356.

Affiliation

Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, NT. gsbite@ferntree.com

Copyright

(Copyright © 2006, Australian Medical Association, Publisher Australasian Medical Publishing)

DOI

unavailable

PMID

16584372

Abstract

Although clinical trials of the antipsychotic amisulpride revealed no cardiac adverse effects, four patients with severe cardiac toxicity after overdose were reported to Australian poisons information centres in 2004-2005. All four had QT prolongation over 500 ms, two had rate-dependent bundle branch block, two developed torsades de pointes, and one died after cardiac arrest. Pending further studies, we recommend electrocardiogram assessment until at least 16 h after amisulpride overdose and, if QT interval is prolonged, cardiac monitoring until the patient is clinically well and conduction intervals are normal.

Language: en