Citation

Jacobus J, McQueeny T, Bava S, Schweinsburg BC, Frank LR, Yang TT, Tapert SF. Neurotoxicol. Teratol. 2009; 31(6): 349-355.

Affiliation

SDSU/UCSD Joint Doctoral Program in Clinical Psychology; VA San Diego Healthcare System.

Copyright

(Copyright © 2009, Elsevier Publishing)

DOI

10.1016/j.ntt.2009.07.006

PMID

19631736

PMCID

PMC2762024

Abstract

Structural brain abnormalities have been observed in adolescents with alcohol use disorders but less is known about neuropathological brain characteristics of teens with subdiagnostic binge drinking or the common pattern of binge drinking combined with marijuana use. The goal of this study was to examine white matter integrity in adolescents with histories of binge drinking and marijuana use. Diffusion tensor imaging (DTI) was conducted with 42 adolescents (ages 16-19) classified as controls, binge drinkers, or binge drinkers who are also heavy marijuana users. Tract based spatial analysis identified shared fiber structure across individuals and facilitated voxelwise comparisons of fractional anisotropy (FA) and mean diffusivity (MD) between groups. Significant between group differences were found in FA in eight white matter regions (ps

Language: en