Citation

Taylor A, Kim-Cohen J. Dev. Psychopathol. 2007; 19(4): 1029-1037.

Affiliation

Social, Genetic and Developmental Psychiatry Centre, Box Number PO80, Institute of Psychiatry, King's College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK. A.Taylor@iop.kcl.ac.uk

Copyright

(Copyright © 2007, Cambridge University Press)

DOI

10.1017/S095457940700051X

PMID

17931432

Abstract

As studies of measured gene-environment interactions (G x E) in developmental psychopathology gain momentum, methods for systematically and quantitatively summarizing effects across multiple studies are urgently needed. Meta-analyses of G x E findings are critical for evaluating the overall statistical and theoretical significance of any given G x E based on cumulative and systematically combined knowledge. Although meta-analytic methods for the combination of study findings based on single effect measures such as odds ratios and mean differences are well established, equivalent methods for the meta-analysis of studies investigating interactions are not well developed. This article describes one simple approach to the meta-analysis of G x E effects using, as a contemporaneous example, the interaction of the monoamine oxidase A (MAOA) gene and the impact of childhood maltreatment on risk for developing antisocial behavior.

Language: en