Citation

Wasserman D, Geijer T, Sokolowski M, Frisch A, Michaelovsky E, Weizman A, Rozanov VA., Wasserman J. Eur. Neuropsychopharmacol. 2007; 17(3): 230-233.

Affiliation

The National and the Stockholm County Centre for Suicide Research and Prevention of Mental Ill-Health, Dep of the Public Health Sciences, Karolinska Institute, Stockholm, Sweden. danuta.wasserman@ki.se

Copyright

(Copyright © 2007, Elsevier Publishing)

DOI

10.1016/j.euroneuro.2006.08.006

PMID

17029913

Abstract

Serotonergic neurotransmission has been implicated in suicidal behavior, including inconsistent results concerning the serotonin transporter promoter polymorphism (5-HTTLPR). Here, we analyzed the 5-HTTLPR in suicide attempters (n=85). Comparing the presence of SS with SL+LL genotypes showed a significantly higher prevalence of the SS genotype in suicide attempters with high medical damage scores (chi2=9.054, df=1, p=0.0026). The results suggest that the S-allele may predispose for suicidal behavior characterized by high determination.

Language: en