Citation

Akinci B, Yener S, Bengi G, Yesil S. Hormones (Athens) 2008; 7(4): 325-329.

Affiliation

Division of Endocrinology and Metabolism, Dokuz Eylul University Medical School, Inciralti, Izmir, Turkey. baris.akinci@deu.edu.tr

Copyright

(Copyright © 2008, Hellenic Endocrine Society)

DOI

unavailable

PMID

19121994

Abstract

It is widely known that metformin reduces the levels of circulating pro-coagulant factors and improve fibrinolytic activity in type 2 diabetes when used in therapeutic doses. Potential alterations of coagulation have not been reported in patients with metformin intoxication. We evaluated certain components of the coagulation system in a patient with metformin intoxication upon admission and after recovery. Our results indicate that both the levels of coagulation proteins synthesized by the liver and the anti-coagulant activity decrease temporarily in metformin intoxication. Nevertheless, no change in the coagulation factors secreted by the endothelium were observed.

Language: en