Citation

Tarter RE, Kirisci L, Gavaler JS, Reynolds M, Kirillova GP, Clark DB, Wu J, Moss HB, Vanyukov M. Biol. Psychiatry 2009; 65(2): 116-121.

Affiliation

Department of Pharmaceutical Sciences, Center for Education and Drug Abuse Research, University of Pittsburgh, School of Pharmacy, Pittsburgh, PA 15261, USA. tarter@pitt.edu

Copyright

(Copyright © 2009, Elsevier Publishing)

DOI

10.1016/j.biopsych.2008.08.032

PMID

18930183

PMCID

PMC2643094

Abstract

BACKGROUND: The role of testosterone in the development of behaviors presaging cannabis use and subsequently cannabis use disorder was investigated in a prospective study of 208 boys. It was theorized that adverse neighborhood correlates with testosterone level that in turn potentiates behaviors predisposing to cannabis consumption and subsequently diagnosis of cannabis use disorder. METHODS: Proportion of boarded-up dwellings in the 1990 census tract and testosterone level were recorded at baseline (ages 10-12), followed by assessments of assaultiveness and testosterone level (ages 12-14), social dominance/norm-violating behavior (SDNVB) (age 16), cannabis use (age 19), and cannabis use disorder (age 22). RESULTS: Percent of vacant dwellings correlates with testosterone level that in turn predicts assaultive behavior sequentially leading to SDNVB, cannabis use, and cannabis use disorder. Externalizing behaviors and cannabis use disorder are not directly predicted by neighborhood quality. CONCLUSIONS: Elevated testosterone level intermediates the association between neighborhood adversity and aggressive socially deviant behaviors presaging cannabis use and cannabis use disorder.

Language: en