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Citation |
Dracheva S, Chin B, Haroutunian V. Neuroreport 2008; 19(3): 379-382. |
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Affiliation |
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA. Stella.Dracheva@mssm.edu |
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Copyright |
(Copyright © 2008, Lippincott Williams and Wilkins) |
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DOI |
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PMID |
18303585 |
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Abstract |
In an earlier study, we showed increases in serotonin 2C receptor (5-HT2CR) pre-mRNA editing in prefrontal cortex that were specific to suicide victims irrespective of associated psychiatric diagnoses. Here we demonstrate that the ratio between the two 5-HT2CR splice variants is increased in people who committed suicide, but does not vary among the diagnostic groups. This provides further evidence for suicide-specific neurobiology and suggests that, as it was previously shown in vitro, 5-HT2CR editing modulates its splicing in human brain. The association analysis indicates, however, that the efficiency of 5-HT2CR editing is an imperfect predictor of the splicing outcome, and that splice site selection is only partially controlled by the level of editing in vivo. Language: en |