Citation

De Luca V, Tharmaligam S, Strauss J, Kennedy JL. Eur. Arch. Psychiatry Clin. Neurosci. 2008; 258(7): 428-433.

Affiliation

Dept. of Psychiatry, University of Toronto, 250 College Street, R-30, Toronto (ON), Canada M5T 1R8. vincenzo_deluca@camh.net

Copyright

(Copyright © 2008, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s00406-008-0815-x

PMID

18504633

Abstract

The serotonin 2C (HTR2C) receptor has been implicated in suicide-related behaviours, however there are not many studies to date about HTR2C and suicidality. We studied HTR2C haplotypes in suicide attempters, where our sample composed of 306 families with at least one member affected by bipolar disorder. HTR2C (Cys23Ser and a common STR in the promoter) variants were analyzed with respect to attempter status and the severity of suicidal behaviour. The X-linked haplotype analysis in relation to suicide attempt did not reveal any significant association. Furthermore, we performed a particular gene-gene interaction for the X-linked serotonergic genes (HTR2C and MAOA), and found no association among this intergenic haplotype combination and suicidal behaviour in bipolar disorder.

Language: en