Citation

Fanton L, Bevalot F, Grait H, Le Meur C, Gaillard Y, Malicier D. J. Forensic Leg. Med. 2008; 15(6): 388-390.

Affiliation

Université Lyon 1, Institut de Médecine Légale, 12 Avenue Rockefeller Lyon, F-69008 Lyon, France. laurent.fanton@adm.univ-lyon1.fr

Copyright

(Copyright © 2008, Elsevier Publishing)

DOI

10.1016/j.jflm.2007.12.006

PMID

18586210

Abstract

The antidepressant milnacipran is a double serotonin/noradrenalin reuptake inhibitor. The low reported incidence of intoxication indicates excellent tolerance in comparison with tricyclic and second generation antidepressants. We report a fatal intoxication associating milnacipran, at blood levels (femoral=21.5 mg/l, cardiac=20 mg/l) 40-fold higher than the usual treatment concentration, and six other molecules (fluoxetine, norfluoxetine, sertraline, cyamemazine, nordazepam and oxazepam) at therapeutic levels. To the best of our knowledge, this is the first reported fatal intoxication involving milnacipran.

Language: en