TY  - JOUR
PY  - 2009//
TI  - Startle response in behaviorally inhibited adolescents with a lifetime occurrence of anxiety disorders
JO  - Journal of the American Academy of Child and Adolescent Psychiatry
A1  - Chronis-Tuscano, Andrea
A1  - Lissek, Shmuel
A1  - Henderson, Heather A.
A1  - Pérez-Edgar, Koraly E.
A1  - Degnan, Kathryn A.
A1  - Helfinstein, Sarah M.
A1  - Reeb-Sutherland, Bethany C.
A1  - Pine, Daniel S.
A1  - Grillon, C.
A1  - Fox, Nathan A.
SP  - 610
EP  - 617
VL  - 48
IS  - 6
N2  - OBJECTIVE: Behaviorally inhibited children face increased risk for anxiety disorders, although factors that predict which children develop a disorder remain poorly specified. The current study examines whether the startle reflex response may be used to differentiate between behaviorally inhibited adolescents with and without a history of anxiety. METHOD: Participants were assessed for behavioral inhibition during toddlerhood and early childhood. They returned to the laboratory as adolescents and completed a fear-potentiated startle paradigm and a clinical diagnostic interview (Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version). Magnitude of the startle reflex was examined at baseline and during cues associated with safety and threat. RESULTS: Only adolescents who showed high levels of behavioral inhibition and had a lifetime occurrence of anxiety disorders showed increased startle reactivity in the presence of safety cues. Neither behavioral inhibition nor diagnosis was related to startle reactivity during threat cues. CONCLUSIONS: These results suggest that neurobiological measures, such as the startle reflex, may be a potential risk marker for the development of anxiety disorders among behaviorally inhibited adolescents. These methods may enhance our ability to identify vulnerable individuals before the development of anxious psychopathology.<p />  <p>Language: en</p>
LA  - en
SN  - 0890-8567
UR  - http://dx.doi.org/10.1097/CHI.0b013e31819f70fb
ID  - ref1
ER  -