TY  - JOUR
PY  - 2009//
TI  - Serotonin receptor HTR1A and HTR2C variants and personality traits in suicide attempters and controls
JO  - Journal of psychiatric research
A1  - Serretti, Alessandro
A1  - Calati, Raffaella
A1  - Giegling, Ina
A1  - Hartmann, Annette M.
A1  - Moller, Hans-Jurgen
A1  - Rujescu, Dan
SP  - 519
EP  - 525
VL  - 43
IS  - 5
N2  - INTRODUCTION: Serotonin has been extensively studied in relation to both personality features and suicidal behaviours. OBJECTIVE: In this study, we considered the association between the serotonin receptor 1A (HTR1A) and 2C (HTR2C) SNPs and personality traits, as measured by the Temperament and Character Inventory (TCI), in a sample of suicide patients and healthy volunteers. METHODS: The SNPs considered were, for HTR1A rs1423691, rs878567 and rs6295, and for HTR2C rs547536, rs2192372, rs6318, rs2428707, rs4272555 and rs1801412. The sample was composed of three groups: two German samples, consisting of a healthy control group of 289 subjects (42.6% males, mean age: 45.2+/-14.9) and a psychiatric patient group of 111 suicide attempters (38.7% males, mean age: 39.2+/-13.6), and an Italian sample, composed of 64 mood disorder patients (35.9% males, mean age: 43.0+/-14.8). In the German samples all the SNPs were investigated, while in the Italian sample only the HTR1A rs6295 and the HTR2C rs6318 SNPs were considered. RESULTS: Controlling for sex, age and educational level, single markers and haplotypes were not or only marginally associated with personality dimensions. CONCLUSIONS: Our study does not support the role of HTR1A and HTR2C gene variants on personality traits in both healthy volunteers and mood disorder patients.<p />  <p>Language: en</p>
LA  - en
SN  - 0022-3956
UR  - http://dx.doi.org/10.1016/j.jpsychires.2008.06.005
ID  - ref1
ER  -