TY  - JOUR
PY  - 2024//
TI  - Traumatic brain injury and sleep in military and veteran populations: a literature review
JO  - NeuroRehabilitation
A1  - Landvater, Jeremy
A1  - Kim, Sharon
A1  - Caswell, Keenan
A1  - Kwon, Caroline
A1  - Odafe, Emamoke
A1  - Roe, Grace
A1  - Tripathi, Ananya
A1  - Vukovics, Christian
A1  - Wang, Johnathan
A1  - Ryan, Keith
A1  - Cocozza, Victoria
A1  - Brock, Matthew
A1  - Tchopev, Zahari
A1  - Tonkin, Brionn
A1  - Capaldi, Vincent
A1  - Collen, Jacob
A1  - Creamer, Jennifer
A1  - Irfan, Muna
A1  - Wickwire, Emerson
A1  - Williams, Scott
A1  - Werner, J. Kent
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Traumatic brain injury (TBI) is a hallmark of wartime injury and is related to numerous sleep wake disorders (SWD), which persist long term in veterans. Current knowledge gaps in pathophysiology have hindered advances in diagnosis and treatment. <br><br>OBJECTIVE: We reviewed TBI SWD pathophysiology, comorbidities, diagnosis and treatment that have emerged over the past two decades. <br><br>METHODS: We conducted a literature review of English language publications evaluating sleep disorders (obstructive sleep apnea, insomnia, hypersomnia, parasomnias, restless legs syndrome and periodic limb movement disorder) and TBI published since 2000. We excluded studies that were not specifically evaluating TBI populations. <br><br>RESULTS: Highlighted areas of interest and knowledge gaps were identified in TBI pathophysiology and mechanisms of sleep disruption, a comparison of TBI SWD and post-traumatic stress disorder SWD. The role of TBI and glymphatic biomarkers and management strategies for TBI SWD will also be discussed. <br><br>CONCLUSION: Our understanding of the pathophysiologic underpinnings of TBI and sleep health, particularly at the basic science level, is limited. Developing an understanding of biomarkers, neuroimaging, and mixed-methods research in comorbid TBI SWD holds the greatest promise to advance our ability to diagnose and monitor response to therapy in this vulnerable population.<p />  <p>Language: en</p>
LA  - en
SN  - 1053-8135
UR  - http://dx.doi.org/10.3233/NRE-230380
ID  - ref1
ER  -