TY  - JOUR
PY  - 2024//
TI  - Comparing suicide completion rates in bipolar I versus bipolar II disorder: a systematic review and meta-analysis
JO  - Journal of affective disorders
A1  - Dev, Donovan A.
A1  - Le, Gia Han
A1  - Kwan, Angela T. H.
A1  - Wong, Sabrina
A1  - Arulmozhi, Akhilan
A1  - Ceban, Felicia
A1  - Teopiz, Kayla M.
A1  - Meshkat, Shakila
A1  - Rosenblat, Joshua D.
A1  - Guillen-Burgos, Hernan F.
A1  - Rhee, Taeho Greg
A1  - Ho, Roger C.
A1  - Cao, Bing
A1  - d'Andrea, Giacomo
A1  - Sundberg, Isak
A1  - McIntyre, Roger S.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Bipolar disorder (BD) has a high disease burden and the highest mortality risk in BD comes from suicide. Bipolar disorder type II (BD-II) has been described as a milder form of bipolar disorder; however, extant literature is inconsistent with this description and instead describe illness burden and notably suicidality comparable to persons with bipolar I disorder (BD-I). Towards quantifying the hazard of BD-II, herein we aim via systematic review and meta-analysis to evaluate the rates of completed suicide in BD-I and BD-II. <br><br>METHOD: We conducted a literature search on PubMed, OVID (Embase, Medline) and PsychINFO databases from inception to June 30th, 2023, according to PRISMA guidelines. Articles were selected based on the predetermined eligibility criteria. A meta-analysis was performed, comparing the risk of completed suicide between individuals diagnosed with BD-I to BD-II. <br><br>RESULTS: Four out of eight studies reported higher suicide completion rates in persons living with BD-II when compared to persons living with BD-I; however, two of the studies reported non-significance. Two studies reported significantly higher suicide completion rates for BD-I than BD-II. The pooled odds ratio of BD-II suicide rates to BD-I was 1.00 [95 % CI = 0.75, 1.34]. LIMITATIONS: The overarching limitation is the small number of studies and heterogeneity of studies that report on suicide completion in BD-I and BD-II. <br><br>CONCLUSION: Our study underscores the severity of BD-II, with a risk for suicide not dissimilar from BD-I. The greater propensity to depression, comorbidity and rapid-cycling course reported in BD-II are contributing factors to the significant mortality hazard in BD-II.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-0327
UR  - http://dx.doi.org/10.1016/j.jad.2024.06.045
ID  - ref1
ER  -