TY  - JOUR
PY  - 2024//
TI  - Childhood maltreatment and risk of metabolic dysfunction-associated steatotic liver disease - evidence of sex-specific associations in the general population
JO  - Journal of psychosomatic research
A1  - Siewert-Markus, Ulrike
A1  - Ittermann, Till
A1  - Klinger-König, Johanna
A1  - Grabe, Hans J.
A1  - Stracke, Sylvia
A1  - Völzke, Henry
A1  - Targher, Giovanni
A1  - Dörr, Marcus
A1  - Markus, Marcello R. P.
A1  - Töpfer, Philipp
SP  - e111829
EP  - e111829
VL  - 183
IS  - 
N2  - BACKGROUND AND AIMS: Childhood maltreatment (CM) is linked to self-reported liver disease in adulthood. However, specific diagnostic entities, e.g., metabolic dysfunction-associated steatotic liver disease (MASLD) as the most frequent chronic liver disease, and sex-differences have previously not been considered. <br><br>METHODS: Cross-sectional analyses were conducted in 4188 adults from a population-based cohort in Northeastern Germany after excluding individuals with excessive alcohol consumption, cirrhosis, or chronic viral hepatitis. CM-exposure was assessed using the Childhood Trauma Questionnaire (CTQ). Liver-related outcomes included serologic liver enzymes, fibrosis-4 score (FIB-4) and, in 1863 subjects who underwent magnetic resonance imaging examination, liver fat content. Sex-stratified linear regression and logistic regression models predicting liver-related outcomes and risk for MASLD, respectively, from overall CTQ scores were adjusted for age, school education, alcohol consumption, and waist circumference. Exploratory analyses investigated effects of CTQ-subscales on liver-related outcomes and risk for MASLD. <br><br>RESULTS: In both sexes, overall CM-exposure was associated with higher levels of serum aspartate aminotransferase and FIB-4 score. In men, effects were mainly driven by physical abuse, and in women by emotional neglect. Only in men, overall CM-exposure (β = 0.70, 95%-CI 0.26-1.13, p = 0.002) and four CTQ-subscales were associated with greater liver fat content, and physical abuse (aOR = 1.22, 95%-CI 1.02-1.46, p = 0.034) and physical neglect (aOR = 1.25, 95%-CI 1.04-1.49, p = 0.015) were associated with higher risk for MASLD. <br><br>CONCLUSIONS: These results suggest sex differences in the association between CM and objective serum and imaging markers of MASLD in adulthood. For men especially, a history of CM-exposure may increase risk of developing MASLD in adulthood.<p />  <p>Language: en</p>
LA  - en
SN  - 0022-3999
UR  - http://dx.doi.org/10.1016/j.jpsychores.2024.111829
ID  - ref1
ER  -