TY - JOUR PY - 2018// TI - Regulation of Proteolysis in the Gram-Negative Bacterial Envelope JO - Journal of bacteriology A1 - Raivio, Tracy L. SP - e00639 EP - 17 VL - 200 IS - 3 N2 - Proteolysis is carefully regulated to prevent the untimely destruction of critical proteins. In this issue of the Journal of Bacteriology, Kim and colleagues identify YjfN as a proteolytic regulator that stimulates the activity of the DegP/HtrA protease of Escherichia coli (S. Kim, I. Song, G. Eom, and S. Kim, J Bacteriol 200:e00519-17, 2018, https://doi.org/10.1128/JB.00519-17). The suicide destruction and transcriptional regulation of YjfN limit its activity to conditions in which there are likely to be many misfolded substrate proteins present.

Language: en

LA - en SN - 0021-9193 UR - http://dx.doi.org/10.1128/JB.00639-17 ID - ref1 ER -