TY  - JOUR
PY  - 2017//
TI  - A re-examination of antidepressant treatment-emergent mania in bipolar disorders: evidence of gender differences
JO  - Acta psychiatrica Scandinavica
A1  - Scott, J.
A1  - Brichant-Petitjean, C.
A1  - Etain, B.
A1  - Henry, C.
A1  - Kahn, J.-p.
A1  - Azorin, J.-m.
A1  - Leboyer, M.
A1  - Bellivier, F.
SP  - 479
EP  - 488
VL  - 135
IS  - 5
N2  - OBJECTIVE: To explore the prevalence and clinical profile of males and females who develop antidepressant treatment-emergent mania (ATEM).  METHOD: From an original sample of 754 patients with BD, we identified ATEM+ cases (n = 75) and ATEM- controls (n = 135) that met stringent criteria. We specifically examined the combinations of clinical factors that best classified males and females as ATEM+ cases.  RESULTS: Seventy-five individuals were classified as ATEM+; 87% of ATEM events occurred during antidepressant monotherapy. Regression analyses demonstrated that the presence of an alcohol and/or substance use disorder [Odds Ratio (OR) 6.37], a history of one or more suicide attempts (OR 4.19) and higher number of depressive episodes per year of illness (OR 1.71) correctly classified 73% of males. In contrast, 84% of females were correctly classified on the basis of a positive history of thyroid disorder (OR 3.23), a positive family history of BD I (OR 2.68) and depressive onset polarity (OR 2.01).  CONCLUSION: Using stringent definitions of ATEM status to reduce the probability of inclusion of false-positive cases and false-negative controls, we identified for the first time that the risk profiles for the development of an ATEM differ significantly according to gender.<p /> <p>Language: en</p>
LA  - en
SN  - 0001-690X
UR  - http://dx.doi.org/10.1111/acps.12728
ID  - ref1
ER  -