TY  - JOUR
PY  - 2019//
TI  - In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation
JO  - Proceedings of the National Academy of Sciences of the United States of America
A1  - Davis, Margaret T.
A1  - Hillmer, Ansel
A1  - Holmes, Sophie E.
A1  - Pietrzak, Robert H.
A1  - DellaGioia, Nicole
A1  - Nabulsi, Nabeel
A1  - Matuskey, David
A1  - Angarita, Gustavo
A1  - Carson, Richard E.
A1  - Krystal, John H.
A1  - Esterlis, Irina
SP  - 11490
EP  - 11495
VL  - 116
IS  - 23
N2  - Recent evidence implicates dysregulation of metabotropic glutamatergic receptor 5 (mGluR5) in pathophysiology of PTSD and suicidality. Using positron emission tomography and [18F]FPEB, we quantified mGluR5 availability in vivo in individuals with PTSD (n = 29) and MDD (n = 29) as a function of suicidal ideation (SI) to compare with that of healthy comparison controls (HC; n = 29). Volume of distribution was computed using a venous input function in the five key frontal and limbic brain regions. We observed significantly higher mGluR5 availability in PTSD compared with HC individuals in all regions of interest (P's = 0.001-0.01) and compared with MDD individuals in three regions (P's = 0.007). mGluR5 availability was not significantly different between MDD and HC individuals (P = 0.17). Importantly, we observed an up-regulation in mGluR5 availability in the PTSD-SI group (P's = 0.001-0.007) compared with PTSD individuals without SI. <br><br>FINDINGS point to the potential role for mGluR5 as a target for intervention and, potentially, suicide risk management in PTSD.<p /> <p>Language: en</p>
LA  - en
SN  - 0027-8424
UR  - http://dx.doi.org/10.1073/pnas.1818871116
ID  - ref1
ER  -