TY  - JOUR
PY  - 2019//
TI  - Industrial, Biocide, and Cosmetic Chemical Inducers of Cholestasis
JO  - Chemical research in toxicology
A1  - Vilas-Boas, Vânia
A1  - Gijbels, Eva
A1  - Cooreman, Axelle
A1  - Van Campenhout, Raf
A1  - Gustafson, Emma
A1  - Leroy, Kaat
A1  - Vinken, Mathieu
SP  - 1327
EP  - 1334
VL  - 32
IS  - 7
N2  - A frequent side effect of many drugs includes the occurrence of cholestatic liver toxicity. Over the past couple of decades, drug-induced cholestasis has gained considerable attention, resulting in a plethora of data regarding its prevalence and mechanistic basis. Likewise, several food additives and dietary supplements have been reported to cause cholestatic liver insults in the past few years. The induction of cholestatic hepatotoxicity by other types of chemicals, in particular synthetic compounds, such as industrial chemicals, biocides, and cosmetic ingredients, has been much less documented. Such information can be found in occasional clinical case reports of accidental intake or suicide attempts as well as in basic and translational study reports on mechanisms or testing of new therapeutics in cholestatic animal models. This paper focuses on such nonpharmaceutical and nondietary synthetic chemical inducers of cholestatic liver injury, in particular alpha-naphthylisocyanate, 3,5-diethoxycarbonyl-1,4-dihydrocollidine, methylenedianiline, paraquat, tartrazine, triclosan, 2-octynoic acid, and 2-nonynoic acid. Most of these cholestatic compounds act by similar mechanisms. This could open perspectives for the prediction of cholestatic potential of chemicals.<p /> <p>Language: en</p>
LA  - en
SN  - 0893-228X
UR  - http://dx.doi.org/10.1021/acs.chemrestox.9b00148
ID  - ref1
ER  -