TY  - JOUR
PY  - 2020//
TI  - Effect of Wortmannilactone F on Trichinella spiralis Enteral in Mice
JO  - Vector Borne and Zoonotic Diseases
A1  - Qin, Yuanhua
A1  - Ren, Yixin
A1  - Yi, Cen
A1  - Chileshe, Nawila
A1  - Chen, Yufeng
A1  - Zheng, Lili
A1  - Dai, Xiaodong
A1  - Dong, Yuesheng
A1  - Cui, Yu
SP  - 205
EP  - 211
VL  - 20
IS  - 3
N2  - Trichinosis is a worldwide zoonotic disease closely related to cultural and dietary habits caused by a nematode Trichinella spp. The drugs for its prevention and treatment are still not thoroughly defined. Wortmannilactone F was used to value the therapeutic effects on the worm reduction rates, change of the intestinal mucosa, and the host's body's immune activity in this experiment. BALB/c mice were orally fed with 200 infective Trichinella spiralis larvae. Then, T. spiralis-infected mice were treated with wortmannilactone F (50, 100, and 200 mg/kg). The number and morphological analysis of adult worm, the expression of Factor associated suicide (Fas), and the level of SIgA in the mice were investigated. Wortmannilactone F showed dose-dependent anthelmintic effects by causing mortality of worms, obvious damaging effects on mature T. spiralis' surface and their digestive systems, decreasing the expression of mice's intestinal mucosa's Fas protein, and reducing intestinal mucosa's level of SIgA secretions. Wortmannilactone F is expected to be a potential therapeutic drug for trichinellosis treatment.<p /> <p>Language: en</p>
LA  - en
SN  - 1530-3667
UR  - http://dx.doi.org/10.1089/vbz.2019.2482
ID  - ref1
ER  -