TY  - JOUR
PY  - 2019//
TI  - Aripiprazole Overdose and Transient 2:1 Second Degree Atrioventricular Block: Only A Coincidence?
JO  - Current drug safety
A1  - Russo, Lucia
A1  - Di Vincenzo, Angelo
A1  - Rizzo, Alessandro
A1  - Rossato, Marco
A1  - Vettor, Roberto
SP  - 155
EP  - 157
VL  - 14
IS  - 2
N2  - BACKGROUND: Atypical antipsychotics, unlike traditional antipsychotics, are considered to have limited cardiovascular side effects, but recent evidence drew attention to potential cardiac rhythm disturbances during aripiprazole therapy. Prolonged QT-interval and increased heart rate were described during treatment with therapeutic doses of aripiprazole, and some reports have even shown relevant arrhythmias, such as ventricular trigeminy and supraventricular tachycardia, in patients treated with this drug.  CASE REPORT: Here, we report a case of a young female who attempted suicide with aripiprazole overdose presenting with a concomitant 2:1 second degree atrioventricular block. Little is known on the cardiac toxicity of atypical antipsychotics in overdose: reporting this case description, far from establishing direct causality.  RESULTS AND CONCLUSION: We would promote further efforts to define the possible effects of the drug on the cardiac conduction system, for a safer management of patients in clinical practice.<p /> <p>Language: en</p>
LA  - en
SN  - 1574-8863
UR  - http://dx.doi.org/10.2174/1574886314666190119120657
ID  - ref1
ER  -