TY  - JOUR
PY  - 2019//
TI  - Ameliorative role of aspirin in paraquat-induced lung toxicity via mitochondrial mechanisms
JO  - Journal of biochemical and molecular toxicology
A1  - Marashi, Sayed Mahdi
A1  - Hosseini, Seyede Fatemeh
A1  - Hosseinzadeh, Massood
A1  - Qadir, Muhammad Farhan
A1  - Khodaei, Forouzan
SP  - e22370
EP  - e22370
VL  - 33
IS  - 9
N2  - Paraquat (PQ) has accounted for numerous suicide attempts in developing countries. Aspirin (ASA) as an adjuvant treatment in PQ poisoning has an ameliorative role. And, it's uncoupling of mitochondrial oxidative phosphorylation role has been well established. The current study aimed at examining the aspirin mechanism on lung mitochondria of rats exposed to PQ. Male rats were randomly allocated in five groups: Control group, PQ group (50 mg/kg; orally, only on the first day), and PQ + ASA (100, 200, and 400 mg/kg; i.p.) groups for 3 weeks. Mitochondrial indices and respiratory chain-complex activities were determined. PQ induced lung interstitial fibrosis; however, ASA (400 mg/kg) led to decrease in this abnormal alteration. In comparison with PQ group, complex II and IV activity, and adenosine triphosphate content in ASA groups had significantly increased; however, reactive oxygen species production, mitochondrial membrane permeabilization, and mitochondrial swelling were significantly reduced. In conclusion, aspirin can alleviate lung injury induced by PQ poisoning by improving mitochondrial dynamics.<p /> <p>Language: en</p>
LA  - en
SN  - 1095-6670
UR  - http://dx.doi.org/10.1002/jbt.22370
ID  - ref1
ER  -