TY  - JOUR
PY  - 2011//
TI  - Toxicokinetics of a dipyridamole (Persantin) intoxication: case report
JO  - Human and experimental toxicology
A1  - Lagas, Jurjen S.
A1  - Wilhelm, Abraham J.
A1  - Vos, René M.
A1  - van den Dool, Erik-Jan
A1  - van der Heide, Yvonne
A1  - Huissoon, Sandra
A1  - Beijnen, Jos H.
A1  - Brandjes, Desiderius P. M.
SP  - 74
EP  - 78
VL  - 30
IS  - 1
N2  - We report a case of a 51-year-old woman who was admitted to the hospital after ingestion of large doses of dipyridamole (12 g), temazepam (1 g) and oxazepam (0.2 g) with suicidal intent. The highest dipyridamole concentration that was measured in serum was 9.2 mg/L, which was paralleled by impaired platelet activation. For temazepam and oxazepam, peak serum concentrations were 8.5 and 1.3 mg/L, respectively. The patient was treated with activated charcoal, magnesium sulfate and aminophylline and could be discharged in good physical condition within 17 hours. This is the first report that provides toxicokinetic data and a corresponding pharmacodynamic effect after an intoxication with dipyridamole.<p /> <p>Language: en</p>
LA  - en
SN  - 0960-3271
UR  - http://dx.doi.org/10.1177/0960327110368696
ID  - ref1
ER  -