TY  - JOUR
PY  - 2010//
TI  - [Extended hemoperfusion in the treatment of acute carbamazepine intoxication]
JO  - Nefrologia
A1  - Peces, R.
A1  - Azorín, S.
A1  - Peces, C.
A1  - Selgas, R.
SP  - 127
EP  - 130
VL  - 30
IS  - 1
N2  - Carbamazepine is used in the treatment of epilepsy, and also prescribed in neuralgic pain syndromes, and certain affective disorders. Carbamazepine intoxication with suicide attempt is a relatively common clinical problem that can result in coma, respiratory depression, arrhythmia, hemodynamic instability and death. The drug's relatively high molecular weight, elevated volume of distribution and intense protein-binding render it difficult to extracorporeal removal, but published experience with hemoperfusion or hemodialysis present variable results. We describe a case report involving carbamazepine intoxication who was successfully treated with charcoal hemoperfusion. With this treatment the half-life of carbamazepine was reduced with rapid lowering of carbamazepine levels and clinical improvement. Based on our experience in this patient and a review of previously reported cases, extended charcoal hemoperfusion should be considered for serious carbamazepine intoxication because free as well as bound drug fractions are eliminated via this technique.<p /> <p>Language: es</p>
LA  - es
SN  - 0211-6995
UR  - http://dx.doi.org/10.3265/Nefrologia.pre2010.Jan.10217
ID  - ref1
ER  -