TY  - JOUR
PY  - 2009//
TI  - Survival after a massive overdose of arsenic trioxide
JO  - Critical care and resuscitation
A1  - Kim, Lawrence H. C.
A1  - Abel, Simon J. C.
SP  - 42
EP  - 45
VL  - 11
IS  - 1
N2  - Arsenic poisoning remains a therapeutic challenge, and outcomes are often poor. An 18-year-old man deliberately ingested termiticide containing a massive dose of arsenic trioxide. Arsenic concentration was 6.3 micromol/L in serum on ICU Day 1, and 253 micromol/L in the first 24-hour urine sample, with a urinary arsenic/creatinine ratio of 84 200 micromol/mol. He was treated with the chelating agent meso-2,3-dimercaptosuccinic acid (DMSA) (replaced by dimercaprol on Days 2-5) and required intensive support for multisystem organ failure, but recovered slowly. Nine weeks after the ingestion the only ongoing clinical issue was persistent but slowly improving peripheral neuropathy.<p /> <p>Language: en</p>
LA  - en
SN  - 1441-2772
UR  - http://dx.doi.org/
ID  - ref1
ER  -