TY  - JOUR
PY  - 2007//
TI  - [Hemoperfusion in the treatment of acute valproic acid intoxication]
JO  - Nefrologia
A1  - Peces, R.
A1  - Fernández, E. J.
A1  - Sánchez, R. J.
A1  - Peces, C.
A1  - Montero, A.
A1  - Selgas, R.
SP  - 370
EP  - 373
VL  - 27
IS  - 3
N2  - Valproic acid is increasingly used in the treatment of epilepsy, and also prescribed for bipolar affective disorders, schizoaffective disorders, schizophrenia and migraine prophylaxis. Valproic acid intoxication with suicide attempt is a relatively common clinical problem that can result in coma, respiratory depression, pancytopenia, hemodynamic instability and death. The drug's relatively low molecular weight, small volume of distribution and saturable protein-binding render it potentially amenable to exracorporeal removal (hemodialysis, hemoperfusion or hemofiltration ), but published experience is scarce. We describe a case report involving valproic acid intoxication with ingestion of ethanol, who was successfully treated with charcoal hemoperfusion. With this treatment the half-life of valproic acid was reduced with rapid lowering of valproic acid levels and clinical improvement. Based on our experience in this patient and a review of previously reported cases, charcoal hemoperfusion should be considered for serious valproic acid intoxication because free as well as bound drug fractions are eliminated via this technique.<p /> <p>Language: es</p>
LA  - es
SN  - 0211-6995
UR  - http://dx.doi.org/
ID  - ref1
ER  -